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Year : 2017  |  Volume : 10  |  Issue : 4  |  Page : 1074-1075
CD4+ count after Malva nut juice supplementation: An observation

1 Vitallife Wellness Center, Bumrungrad International Hospital, Bangkok, Thailand
2 Wiwanitkit House, Bangkhae, Bangkok, Thailand

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Date of Web Publication5-Oct-2017

How to cite this article:
Chaiyasit K, Wiwanitkit V. CD4+ count after Malva nut juice supplementation: An observation. Ann Trop Med Public Health 2017;10:1074-5

How to cite this URL:
Chaiyasit K, Wiwanitkit V. CD4+ count after Malva nut juice supplementation: An observation. Ann Trop Med Public Health [serial online] 2017 [cited 2021 Apr 14];10:1074-5. Available from:

At present, the use of complementary medicine for promoting immunity is very interesting in the public health system. Immunomodulation due to natural product is a very interesting process. Sultan et al. noted that several plants were advantageous to human immunity. Sultan et al. proposed that “actions include boosting and functioning of immune system, activation and suppression of immune specialized cells, interfering in several pathways that eventually led to improvement in immune responses and defense system.”[1] Many natural products from several plants are available at present. However, the effect of herbal products on immune response is seldom studied.[2] The pathophysiological explanation on this aspect is very interesting.

Of several plants, Malva nut (Scaphium macropodium) is presently used as food supplementation.[3] The polysaccharide composition of Malva nut has been proved for immunity-stimulating activity in vitro.[4] However, there has never been a report on in vivo activity.

Here, the authors report on the observation on CD4+ count after Malva nut juice supplementation.

The patient is a 22-year-old Thai male with first diagnosis of HIV infection 1 month back. At presentation, his viral load was equal to 4,320 copies/ml log 3.64 and immunological laboratory results were as follows: CD4+ = 25.07%, CD4+ count = 515 cell/mm 3, CD8+ = 35.56% and CD8+ count = 760 cell/mm 3. The patient decided not to get antiretroviral therapy, but asked for alternative treatment by nutritional management. The case was sent to nutritional management clinic.

The patient did not receive any diet modification but only Malva nut juice 250 cm 3 per day. There is no other concomitant treatment. One month later, the immune profile is as follows: CD4+ = 27.4%, CD4+ count = 620 cell/mm 3, CD8+ = 40.7% and CD8+ count = 921 cell/mm 3.

The patient felt happy with the supplementation without any complaint.

The authors got written consent from the patient for reporting the case.

Malva nut is a tree seen in southeast Asia. Its common habitat is tropical jungle. The height of the Malva nut tree can be up to 45 m. It has green leaves and flowers. However, the part that is mentioned in medicine is the seed. The seed of Malva nut looks like a fingertip with brown color (size about 5 cm). It has been used in traditional medicine for a long time. Malva nut is confirmed for usefulness in metabolic control in human being,[3] but there is lack of knowledge about it other aspects. Of interest, there are some reports on the effect of Malva nut in increased immunity in in-vitro test and animal model.[4],[5] On the basis of T-lymphocyte proliferation test, enhancement of T-cell function can be observed in vitro.[4] However, the effect on human beings has never been shown. The present report shows improvement in CD4+ count in the patient. This is the first world report on observation of the effect of Malva nut juice supplementation on CD4+ count in human beings and HIV-infected patient. Although this is only a single case report, this is a useful preliminary data on in-vivo effect of Malva nut on human T cells.

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Conflicts of interest

There are no conflicts of interest.

   References Top

Sultan MT, Butt MS, Qayyum MM, Suleria HA, Immunity: plants as effective mediators. Crit Rev Food Sci Nutr 2014;54:1298-308.  Back to cited text no. 1
Wilasrusmee C, Siddiqui J, Bruch D, Wilasrusmee S, Kittur S, Kittur DS, In vitro immunomodulatory effects of herbal products. Am Surg 2002;68:860-4.  Back to cited text no. 2
Al Muqarrabun LM, Ahmat N, Aris SR, Shamsulrijal N, Baharum SN, Ahmad R, et al. A new sesquiterpenoid from Scaphium macropodum (Miq.) Beumee. Nat Prod Res 2014;28:597-605.  Back to cited text no. 3
Burana-Osot J, Pattanapanyasat K, Soonthornchareonnon N, Sukapirom K, Toida T, Characterisation and immuno-stimulating activity of polysaccharides from Thai medicinal plants. Nat Prod Res 2010;24:1403-12.  Back to cited text no. 4
Namwong N, Panomai N, Thaingamsilp P, The effect of Malva nut beverage consumption with nutrition education on body weight and lipidemia in overweight and obese Kalasin Hospital's Officers. KKU J Pub Health Res 2013;6:39-45.  Back to cited text no. 5

Correspondence Address:
Kamon Chaiyasit
Vitallife Wellness Center at Bumrungrad International Hospital, Bangkok
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1755-6783.196681

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