Annals of Tropical Medicine and Public Health
Home About us Ahead Of Print Instructions Submission Subscribe Advertise Contact e-Alerts Editorial Board Login 
Users Online:733
  Print this page  Email this page Small font sizeDefault font sizeIncrease font size
Year : 2017  |  Volume : 10  |  Issue : 6  |  Page : 1656-1660

Analysis of the association between IL-23R rs11209026 polymorphism in rheumatoid arthritis and systemic lupus erythematosus in an Iranian population

1 Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran
2 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
4 Razi Herbal Medicines Research Center and School of Allied Medical Sciences, Department of Hematology and Blood Transfusion, Lorestan University of Medical Sciences, Khorramabad, Iran

Correspondence Address:
Ali Asghar Kiani
Department of Hematology and Blood Transfusion, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ATMPH.ATMPH_571_17

Rights and Permissions

Introduction: Rheumatoid arthritis(RA) and systemic lupus erythematosus(SLE) are two autoimmune inflammatory diseases with possible genetic links. In this study, the polymorphism R381Q IL-23R in patients with RA, SLE, and healthy controls and its relation to genotype was investigated. Materials and Methods: In this case-control study of 100patients with SLE, 100patients with RA and 112 healthy individuals who were referred to the rheumatology ward of some hospitals in Khorramabad(Lorestan province, west of Iran) were selected. Genomic DNA was extracted from peripheral blood and genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism method. Fisher's exact test was used to compare data from genotypes and alleles between all groups. Results: It was found that polymorphism A>G rs11209026 of IL-23R gene in the control group and patients with RA had significant difference(P=0.046). However in the control group and SLE patients, there was no significant difference(P=0.51). Conclusion: The results indicate that single nucleotide polymorphism rs11209026 G>A of the IL-23R gene is possibly associated with RA. IL-23 is an important inflammatory cytokine and essential for the differentiation of Th17cells. Hence studies related to the role of Th17cells in the pathogenesis of RA would help provide more insights into its regulatory mechanisms.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded19    
    Comments [Add]    

Recommend this journal