Change of platelet count during hospitalization in patients with Ebola virus disease

How to cite this article:
Wiwanitkit S, Wiwanitkit V. Change of platelet count during hospitalization in patients with Ebola virus disease. Ann Trop Med Public Health 2016;9:208-9

 

How to cite this URL:
Wiwanitkit S, Wiwanitkit V. Change of platelet count during hospitalization in patients with Ebola virus disease. Ann Trop Med Public Health [serial online] 2016 [cited 2017 Nov 14];9:208-9. Available from: https://www.atmph.org/text.asp?2016/9/3/208/179119

Dear Sir,

Ebola virus disease is the new emerging viral infection. It is a disease with severe clinical manifestation and critical care is usually required. The platelet change is a common finding in patients with the Ebola virus disease. However, the change of platelet count during the course of illness has not been well-mentioned. Here, the authors analyzed the available data on platelet count among the hospitalized patients with Ebola virus disease in reported cases. From seven reports on 20 hospitalized patients with Ebola virus disease, all had thrombocytopenia on the hospitalization day.[1],[2],[3],[4],[5],[6],[7] This can confirm the nature of hemorrhagic disease. Further studying on two reports on three patients with available data on platelet change during hospitalization, the lowest peak of decreased platelet level can be detected between day 14 and day 17 of illness (average 16 ± 1.7). After that period, the platelet count slightly increases. Focusing on the lowest platelet count, it was between 10 and 46 × 103/mm 3 (average 22.0 ± 20.8 × 103/mm 3) and the magnitude of decreased platelet count from the first observed platelet count at hospitalization (between 20 and 103 × 103/mm 3; average 51.0 ± 45.3 × 103/mm 3) was between 10 and 57 × 103/mm 3 (average 24.0 ± 29.7 × 103/mm 3). It can be seen that platelet count usually decreases between 2 and 3 weeks of illness and the decrease is about 50% of the level detected on first hospitalization. Nevertheless, the authors’ conclusions from the available data might be partial, biased by the current reported cases as controlled platelet count measurements were not performed. This letter can support a current literature on the disease. Although, at present, the disease might be no longer considered a hemorrhagic fever due to the paucity of hemorrhagic manifestations and the lack of clear correlation to platelet count and bleeding, the present report still present the importance of platelet follow-up in patient care.[8]

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References

 

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Kraft CS, Hewlett AL, Koepsell S, Winkler AM, Kratochvil CJ, Larson L, et al.; Nebraska Biocontainment Unit and the Emory Serious Communicable Diseases Unit. The use of TKM-100802 and convalescent plasma in 2 patients with Ebola virus disease in the United States. Clin Infect Dis 2015;61:496-502.
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Lyon GM, Mehta AK, Varkey JB, Brantly K, Plyler L, McElroy AK, et al.; Emory Serious Communicable Diseases Unit. Clinical care of two patients with Ebola virus disease in the United States. N Engl J Med 2014;371:2402-9.
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Kreuels B, Wichmann D, Emmerich P, Schmidt-Chanasit J, de Heer G, Kluge S, et al. A case of severe Ebola virus infection complicated by gram-negative septicemia. N Engl J Med 2014;371:2394-401.
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WHO Ebola Response Team. Ebola virus disease in West Africa – The first 9 months of the epidemic and forward projections. N Engl J Med 2014;371:1481-95.

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/1755-6783.179119

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