One of the most effective ways to treat women with polycystic ovarian syndrome (PCOS) is to use an estrogen-based therapy, such as clomiphene. This treatment is currently the first-line treatment for PCOS. However, there are now new treatment options, including the use of aromatase inhibitors. Those with PCOS should talk to their doctor about these options.
The current study included 750 women with polycystic ovaries and was done in two groups. The two groups were well-matched at the beginning of the trial. The last patient finished taking the medication in July 2012, and the last reported pregnancy was in February 2013. The study was terminated early due to the withdrawal of 158 women. The reason for their withdrawal from the study was not statistically significant.
The current study, titled Clomiphene Citrate in Women With PCOS: A Multicenter Study, is a comprehensive review of the available studies. It found that it did not affect fertility in women with PCOS. However, it failed to detect any adverse effects. It did not reveal any negative side effects. Its primary goal was to determine whether clomiphene citrate improved fertility in infertile women.
A modern approach to the disease is laparoscopic ovarian drilling (LOD). In this method, ovulation is induced by using a laser or electrical energy. During the procedure, the ovaries are drilled in order to reduce the amount of cells that produce testosterone. During the procedure, the ovulation rate and pregnancy rate are assessed. Moreover, the results of the procedure are followed over a period of time.
The drilling procedure is a common method of ovulation induction. Although it is not an ideal treatment for PCOS, it is considered a safe and effective alternative to other gonadotropin-based treatments. Its success rate ranges from 15% to 40%, although it may be ineffective for all patients. The treatment is not effective for all women with PCOS. Some women who are CC resistant may be better candidates for another treatment.
Some women with PCOS are unable to respond to clomiphene. They may have high levels of FSH or are undergoing a previous surgery or radiation. These patients do not respond to clomiphene. In addition, they have visual problems or may have hypothyroidism. Therefore, a woman with PCOS may be infertile or have a miscarriage.
Compared to a placebo, clomiphene citrate is an effective treatment for PCOS. The drug inhibits EBOV infection in cells. It protects mice from EBOV challenge. Its two stereoisomers agglutamine and ethylmeride inhibit the expression of the EBOV. These drugs block the activity of the EBOV.