In a recent study, the relationship between NS1 antigen and thrombopenia in suspected dengue cases was investigated. Both antibody-specific and cross-reactive antibodies to the NS1 peptide correlated with thrombocytopenia. In addition, a direct correlation between platelet aggregation and NS1 was also found.
The findings of the study showed that thrombocytopenia and NS1 antigen were significantly associated with clinical and laboratory parameters in dengue suspicious cases. In adults, NS1 and thrombocytopenia are more frequently detected in patients with suspected dengue, which may help in the diagnosis. Moreover, a positive NS1 antigen test is a useful diagnostic tool in patients with suspected dengue.
The acute febrile phase of dengue is characterized by fever lasting between two to seven days and is associated with a rash of “islands of white in a sea of red.” Some patients may also develop a classical rash of “isles of white in a sea of red”. During the defervescence phase, WBC and platelet counts begin to rise. The platelet count usually normalizes a day or two later, depending on social factors and laboratory results.
Thrombocytopenia and NS1 antigen are the most common laboratory tests for suspected dengue. These parameters can be used to differentiate dengue from other viral infections. Moreover, the results can be interpreted with caution. However, it is imperative that the patient undergoes clinical diagnosis and laboratory confirmation. The disease is characterized by a series of overlapping clinical manifestations, including plasma leakage, decreased intravascular volume, and altered mental status.
Patients with severe dengue should be monitored closely. Any patient with bleeding symptoms, evidence of fluid leakage, or an elevated platelet count should be treated immediately. NS1 antigen and thrombopenia are also the best markers for suspicion of severe dengue. The presence of NS1 is a key indicator of severe disease. When comparing NS1 antigen with thrombocytopenia, it is important to look for an overall score of the disease.
The findings of the study are encouraging. The findings are consistent with the findings of earlier studies. There is no clear correlation between the two, but there is evidence that one of the NS1 antigen and thrombopenia in dengue pregnant women is related to the timing of the disease. The risk of vertical transmission is low, but the risk of fetal infection during pregnancy is substantial.
The increasing number of dengue cases is partly explained by a change in national practices in reporting dengue to the World Health Organization. The increase is an indication that governments recognize the disease burden and are taking steps to report it accurately. The growth observed brings us closer to a more accurate assessment of the full burden of dengue. So, if you suspect a patient has dengue infected with NS1 antigen, it is advisable to seek medical help.
Specific antibody detection of dengue is the mainstay of diagnosis. While it is very specific, it is prone to false positive and negative reactions. NS1 has been shown to be highly specific for the diagnosis of dengue infection in humans. In the peripheral laboratory, platelet counts are the only accessory test for determining a diagnosis of dengue. When NS1 is detected, the diagnosis is a definitive diagnosis.
The presence of NS1 antigen and thrombopenia in dengue is highly suggestive of the disease. Symptoms of severe dengue infection include evidence of fluid leakage, bleeding manifestations, and platelet count >25,000 cells/mm3. The NS1 antigen is also detected by IgM and IgG antibodies, and both are positive.
NS1 antigen and thrombopenia are often associated. Although the NS1 antigen and thrombocytic factors are not the only determinants of a diagnosis of dengue, they are important for the evaluation of the disease. In some cases, the NS1 antigen alone is not sufficient to diagnose dengue, but it can help in establishing the diagnosis of other diseases.